Can Synthetic Cannabinoids Help Regulate Arterial Pressure?

According to the specialist of the University of Colima (UCOL), this type of research can help in understanding the mode of action of cannabinoids, as well as their medicinal properties, which will allow development of drugs to help regulate muscle tone with a reduced chance of side effects.

The potential benefits of medical hemp to alleviate and ameliorate the symptoms of diseases such as epilepsy, Parkinson's and several others have been demonstrated throughout hundreds of scientific studies. The University of Colima conducted a study where researchers tried to analyze the possible pharmacological application of synthetic cannabinoids in the regulation of blood pressure of diabetic and arteriosclerosis patients.

What are Synthetic Cannabinoids?

According to the National Institute on Drug Abuse (NIH), synthetic cannabinoids refer to an increasing number of mind-altering chemical compounds, which belong to the family of chemical compounds found in the hemp plant.

Synthetic cannabinoids belong to a class of unregulated drugs called "new psychotropic substances" that are supposed to mimic the effects of some drugs.

The basis of the Study on Synthetic Compounds of Hemp and Vascular System

In the research conducted by UCOL, synthetic cannabinoids regulated by the Drug Control Administration (DEA) are used.

According to Dr. Enrique Sánchez Pastor, head of the research, he states that cannabinoids exert their effect mainly through receptors, which are proteins that are expressed in the cell membrane of different tissues of different organisms, including humans. For example, CB1 receptors are found mainly in the central nervous system and CB2 receptors in the immune system.

From the previous image, we can see that both types of receptors are found in arterial tissue.

The following pieces of evidence were found in the investigation:

  • CB-1 receptor: Induces relaxation of the aorta artery.
  • CB-2 receptor: Causes narrowing of the blood vessel.

The objective of the study was to elucidate the mechanisms of action of cannabinoids and endocannabinoids, by extracting the aorta artery of animals in order to observe the application effects in artery tension.


Results of the Application of Cannabinoids and Blood Pressure

After carrying out the tests marked by the research, the effects of the application of cannabinoids in animal models with the following induced pathologies are:

  • Arteriosclerosis: The arteries become stiff and it is observed that the effect of cannabinoids is more pronounced than in healthy animals.

  • Diabetes: Effects similar to the previous one, however, in these animals the arteries have a flaccid feature. (The animals were aggressive).

According to the specialist of the UCOL, this type of research can help to know the mode of action of cannabinoids, as well as their medicinal properties, which will allow the development of drugs to help regulate muscle tone, provided that eliminate the side effects.

Please visit Medical Hemp for more information on CBD research.

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